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MiRNA expression profiles of MDA-MB-231 TNBC cells with defected RARalpha serine-77 phosphorylation

ABSTRACT: microRNAs have been shown to be involved in the pathogenesis of TNBC as important regulators of cell proliferation and apoptosis. However, whether the activation of retinoic acid receptor alpha (RARα), a transcription factor, is involved in mediating transcriptional regulation of microRNAs remains elusive. Here, we investigated the differentially expressed miRNAs in triple negative breast cancer cell line MDA-MB-231 overexpressing a phosphorylation-defective mutant RARαS77A, which mimicked activated RARα, in comparison to non-transfected control cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE160295 | GEO | 2021/05/05

REPOSITORIES: GEO

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