Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE160310 | GEO | 2021/04/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (smallRNA)

Project description:Diabetic Retinopathy (DR) is among the major global causes for vision loss. With the rise in diabetes prevalence, an increase in DR incidence is expected. Current understanding of both the molecular etiology and pathways involved in the initiation and progression of DR is limited. Here we analyzed mRNA and miRNA expression profiles of 80 human post-mortem retinal samples from 80 patients diagnosed with various stages of DR. We found differentially expressed transcripts to be predominantly associated with late stage DR and pathways such as hippo and gap junction signaling. A multivariate regression model identified transcripts with progressive changes throughout disease stages, which in turn displayed significant overlap with sphingolipid and cGMP−PKG signaling. Combined analysis of miRNA and mRNA expression further uncovered disease-relevant miRNA/mRNA associations as potential mechanisms of post-transcriptional regulation. Finally, integrating human retinal single cell RNA-Sequencing data revealed a continuous loss of retinal ganglion cells, and Müller cell mediated changes in histidine and β-alanine signaling. Our findings offer an unprecedented insight into the development of DR and provide potential avenues for future therapeutic intervention.

2021-04-19 | GSE160308 | GEO

In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (totalRNA)

2021-04-19 | GSE160306 | GEO

In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy

Project description:In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy

| PRJNA672925 | ENA

In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (totalRNA)

Project description:In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (totalRNA)

| PRJNA672928 | ENA

In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (smallRNA)

Project description:In-depth transcriptomic analyses investigating molecular mechanisms underlying diabetic retinopathy (smallRNA)

| PRJNA672929 | ENA

In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy.

Project description: Not available

| S-EPMC8131353 | biostudies-literature

In-depth transcriptomic analyses investigating molecular mechanisms underlying the osteogenic differentiation of human renal interstitial fibroblasts.

Project description:Randall’s plaques (RP) are well established as precursor lesions of idiopathic calcium oxalate (CaOx) stones, and the process of biomineralization driven by osteogenic-like cells has been highlighted in RP formation, but the mechanism is poorly understood. Given the potential role of osteogenic-like renal interstitial fibroblasts in biomineralization, the isolated primary human renal interstitial fibroblasts (hRIFs) were either induced with a widely used osteogenic medium or cultured in normal medium for 7 days, and a transcriptomic analysis of LncRNA and mRNA was performed to study molecular mechanisms underlying the osteogenic differentiation of human renal interstitial fibroblasts.

2022-05-19 | GSE203110 | GEO

In-depth transcriptomic analyses investigating molecular mechanisms underlying the osteogenic differentiation of human renal interstitial fibroblasts.

Project description:In-depth transcriptomic analyses investigating molecular mechanisms underlying the osteogenic differentiation of human renal interstitial fibroblasts.

| PRJNA838590 | ENA

Transcriptomic analyses reveal molecular mechanisms underlying growth heterosis and weakness of rubber tree seedlings.

Project description: Not available

| S-EPMC5759766 | biostudies-literature

Investigating the Mechanisms of Pollen Typhae in the Treatment of Diabetic Retinopathy Based on Network Pharmacology and Molecular Docking.

Project description: Not available

| S-EPMC8747905 | biostudies-literature