Identification of LARP1 targets in naive CD4 T cells [eCLIP]

ABSTRACT: We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These LARP1 eCLIP experiments determine the RNA binding sites of LARP1 in naive CD4 T cells from Rnmt cKO and control mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE160325 | GEO | 2021/05/13

REPOSITORIES: GEO