RNMT regulates the activated CD4 T cell transcriptome and translatome [Ribo-Seq]

ABSTRACT: We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These ribosome footprinting experiments investigate the effect of Rnmt cKO on the activated CD4 T cell transcriptome and translatome.

ORGANISM(S): Mus musculus

PROVIDER: GSE160326 | GEO | 2021/05/13

REPOSITORIES: GEO