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AhR mutant vs N2 wild-type C.elegans, in L1 larval stage

ABSTRACT: Expression profiles of AhR mutant vs N2 wild-type C.elegans, in L1 larval stage compared by using 23232 feature WUSTL microarray

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE16036 | GEO | 2009/12/19

SECONDARY ACCESSION(S): PRJNA115397

REPOSITORIES: GEO

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AhR mutant vs N2 wild-type C.elegans, in L1 larval stage

Project description:Expression profiles of AhR mutant vs N2 wild-type C.elegans, in L1 larval stage compared by using 23232 feature WUSTL microarray 4 ahr-mutant worm samples compared to 3 wild-type samples. Total RNAs purified and reverse transcribed to cDNA and labeled with Cy3-dUTP, and then hybridized on microarray.

2010-05-16 | E-GEOD-16036 | biostudies-arrayexpress

Caenorhabditis elegans

Project description:AhR mutant vs N2 wild-type C.elegans, in L1 larval stage

| PRJNA115397 | ENA

RNA-seq for C.elegans lin-52 vs N2 (UV & non-UV)

Project description:RNA-seq was applied for identifying the change of transcriptome between L1 stage lin-52 mutants and N2, with and without UV after 6h of irradiation.

2023-02-01 | GSE152235 | GEO

RNA-seq of N2 and HBR227 worms in L1 arrest (48 hours)

Project description:We report the gene expression in L1 arrest (48 hours) of wild-type sleeping worms (N2) and aptf-1(gk794) mutant sleepless worms (HBR227)

2022-02-28 | GSE196158 | GEO

RNA-seq of N2, HBR2340 and PHX2193 worms in L1 arrest (48 hours)

Project description:We report the gene expression in L1 arrest (48 hours) of wild-type sleeping worms (N2) and RIS-manipulated worms (HBR2340 and PHX2193)

2022-02-28 | GSE196380 | GEO

mRNA-seq analysis of Caenorhabditis elegans N2 and irld-39(duk1); irld-52(duk17) throughout L1 starvation

Project description:Whole starved L1 larvae were collected at 5 time points between 6 and 72 hours from two strain backgrounds, N2 and LRB444

2023-01-06 | GSE174318 | GEO

Transcriptome profiling of mutant ASH2,RBBP5,WDR5 and WT(N2 or wild type) of C.elegans by RNASeq

Project description:We used four C. elegans strains: N2(wild type), wdr-5(ok1417) III, rbbp-5(tm3463) II, and ash-2(tm1905) II. By sequence the mRNAs from embryos of these worms we try to assess the effect of these mutations in gene regulation of C.elegans.

2023-10-19 | E-MTAB-5500 | biostudies-arrayexpress

Identification of Transcription Factor N2::POL II Binding Regions in L1

Project description:modENCODE_submission_2437 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is tagged with the same GFP fusion protein, permitting validation of the gene's correct spatio-temporal expression pattern in transgenic animals. Chromatin immunoprecipitation on each strain is peformed using an anti-GFP antibody, and any bound DNA is deep-sequenced using Solexa GA2 technology. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf EXPERIMENT TYPE: CHIP-seq. BIOLOGICAL SOURCE: Strain: N2(genotype : wild type genotype : DR subclone of DB original (Tc1 pattern I) official name : N2 ); Developmental Stage: fed L1; Genotype: wild type; Sex: Hermaphrodite; EXPERIMENTAL FACTORS: Developmental Stage fed L1; Target gene ama-1; Strain N2(genotype : wild type genotype : DR subclone of DB original (Tc1 pattern I) official name : N2 ); temp (temperature) 20 degree celsius Series_type: CHIP-seq

2011-02-18 | E-GEOD-25790 | biostudies-arrayexpress

Transcription profiling of zebrafish larval regenerating fin tissue after exposure to TCDD in order to identify genes differentially regulated after Ahr activation

Project description:Exposures to dioxin, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause a wide array of toxicities in vertebrates and is mostly considered to be mediated through the inappropriate activation of the aryl hydrocarbon receptor (Ahr) signaling pathway. Although transcriptional regulation by Ahr is widely studied, the molecular mechanisms responsible for the adverse outcomes after Ahr activation are largely unknown. To identify the important events downstream of AHR activation that play an actual role in the toxic responses, we employed the zebrafish caudal fin regeneration models since Ahr activation blocks the regenerative process. Zebrafish regenerate their caudal fins by an orchestrated progression of cell migration, differentiation and proliferation controlled by a multitude of signaling pathways. This complex process was exploited as an in vivo platform to identify cross talk between Ahr and other signaling pathways. Global genomic analysis was performed in the larval regenerating fin tissue after exposure to TCDD in order to identify genes differentially regulated after Ahr activation. Comparative toxicogenomic analysis revealed that both adult and larval fins respond to TCDD during regeneration with mis-expression of Wnt signaling pathway members and Wnt target genes. Experiment Overall Design: The caudal fin of zebrafish larvae at 2days post fertilization were amputated and exposed to vehicle control alone or TCDD. Regenerating fins were isolated at 2and 3 days post amputation. Three replicates were collected at each time point. 150 fins were pooled to comprise one replicate.

2008-04-07 | E-GEOD-10184 | biostudies-arrayexpress

Analysis of gene expression between monomethyl branched-chain fatty acid deficient (elo-5) and wild type N2 C. elegans L1 larvae hatched on food-free NGM plates

Project description:Gene expresssion is not globally shut down in elo-5 as compared to N2 Many changes in metabolic and regulatory gene expression were detected between elo-5 and N2 L1 larvae.

2016-01-14 | GSE64973 | GEO

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