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RNAseq transcriptome analysis of Streptococcus pneumoniae 23F treated with PBT2 and zinc

ABSTRACT: Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response uses various chemical insults to control infection, including metal stress mediated by localized changes in zinc abundance. Here, we characterized the impact of S. pneumoniae zinc intoxication revealing disruptions in central carbon metabolism, lipid biogenesis and peptidoglycan biosynthesis. To dysregulate zinc homeostasis in the wild-type strain, we investigated the safe-for-human use ionophore PBT2. PBT2 rendered wild-type S. pneumoniae strains sensitive to a range of antibiotics.

ORGANISM(S): Streptococcus pneumoniae

PROVIDER: GSE160372 | GEO | 2021/10/01

REPOSITORIES: GEO

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RNAseq transcriptome analysis of Streptococcus pneumoniae 23F treated with PBT2 and zinc

Project description:RNAseq transcriptome analysis of Streptococcus pneumoniae 23F treated with PBT2 and zinc

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