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Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor

ABSTRACT: Previous studies suggested that XBP1s is important in deciding cell fate during the UPR, however, the mechanistic details of how it modulates this transition are limited. To search for XBP1s transcriptional targets, we utilized an XBP1s-inducible human cell line to limit XBP1 expression in a controlled manner.

ORGANISM(S): Homo sapiens

PROVIDER: GSE160416 | GEO | 2021/10/12

REPOSITORIES: GEO

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Profiling gene expression in 32Dcl3 cells following Xbp1 retrovirus vector transfection

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Profiling gene expression in 32Dcl3 cells following Xbp1 retrovirus vector transfection

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Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor.

Project description: Not available

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Expression data from human multiple myeloma cells with or without IRE1-XBP1 silencing

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