Host response to RhCMV/SIV immunization through subcutaneous and oral route

ABSTRACT: Strain 68-1–derived Rhesus Cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that stringently control and subsequently clear a mucosal challenge with highly pathogenic SIV in 50-60% of vaccinated rhesus monkeys (RMs). Here, we utilize whole blood transcriptomic profiling to identify host responses correlated to RhCMV/SIV efficacy.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE160562 | GEO | 2021/06/28

REPOSITORIES: GEO