Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [ATAC-Seq]

ABSTRACT: ATAC sequencing was performed to evaluate epigenetic changes induced by the bone microenvironment. We found a global epigenetic reprogramming of ER+ cancer cells deriving from bone which drives stemness and endocrine resistance

ORGANISM(S): Homo sapiens

PROVIDER: GSE160582 | GEO | 2021/04/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [Evolving Barcode]

Project description:Evolving barcode was used to evaluate clonal expansion in bone metastases induced by intra-iliac artery injection. The assocoation of these results with ER expression revealed a non-genomic effect of the bone microenvironment on ER heterogeneity.

2021-04-16 | GSE160566 | GEO

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [exome-seq]

Project description:Whole Exome Sequencing (WES) was used to evaluate genomic alterations between parental cells, SCPs (Single Cell-derived Subpopulations) and bone-entrained cells.

2021-04-16 | GSE161181 | GEO

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-16 | GSE160583 | GEO

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [MCF7]

Project description:Translating Ribosome Affinity Purification (TRAP) sequencing revealed that human osteogenic cells (FOB1.19) strongly alter the transcriptional profile of ER+ breast cancer cells (MCF7) in 3D coculture system.

2021-04-16 | GSE137270 | GEO

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells

Project description:Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells

| PRJNA673695 | ENA

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells[Osteogenic cells]

Project description:RNA sequencing was used to evaluate the effect of cancer cells on osteogenic cells (FOB 1.19) in presence of estrogen or androgen. Here, we unbiasely evaluated the expression level of fibroblast growth factor receptors (FGFs) in osteogenic cells (FOB) alone.

2021-04-16 | GSE137245 | GEO

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [MCF7]

Project description:Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [MCF7]

| PRJNA564988 | ENA

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [exome-seq]

Project description:Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [exome-seq]

| PRJNA675832 | ENA

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells[Osteogenic cells]

Project description:Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells[Osteogenic cells]

| PRJNA564854 | ENA

Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [Evolving Barcode]

Project description:Impact of the bone microenvironment on phenotypic plasticity of ER+ breast cancer cells [Evolving Barcode]