Transcriptomics,Genomics

Dataset Information

69

Mutated IGHV3-23 CLL


ABSTRACT: Expression of stereotyped B cell receptors (BCR), i.e. non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes, complementarity-determining region-3 (HCDR3), and IGV light chains, identifies discrete clusters and represents a peculiar feature of chronic lymphocytic leukemia (CLL). Expression of IGHV3-23 characterized a CLL subset with peculiar molecular and clinical features. Overall design: Two-condition experiment, Mutated IGVH3-23 vs. Mutated non-IGVH3-23. Biological replicates: 22 control replicates, 5 Mutated IGVH3-23 replicates. Refrence design

INSTRUMENT(S): Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)

SUBMITTER: daniela marconi  

PROVIDER: GSE16065 | GEO | 2009-06-13

SECONDARY ACCESSION(S): PRJNA115487

REPOSITORIES: GEO

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Publications


PURPOSE: B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease whose outcome can be foreseen by investigating the mutational status of immunoglobulin heavy chain variable (IGHV) genes. Moreover, a different prognosis was reported for CLL expressing specific IGHV genes in the context or not of stereotyped B-cell receptors. Here we investigated novel associations between usage of specific IGHV genes and clinical features in CLL. EXPERIMENTAL DESIGN: Among 1,426 CLL-specif  ...[more]

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