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Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Xenopus laevis

PROVIDER: GSE16075 | GEO | 2010/01/01

SECONDARY ACCESSION(S): PRJNA115501

REPOSITORIES: GEO

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Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver

Project description:This SuperSeries is composed of the following subset Series: GSE16017: Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part B GSE16018: Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C GSE16074: Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A Refer to individual Series

2010-05-16 | E-GEOD-16075 | biostudies-arrayexpress

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A

Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: cell cycle design,co-expression design,reference design,time series design Thyroid hormone (TH) controls remodeling of the pancreas. The micro array was carried out to identify changes in gene expression between the tadpole and frog pancreas. This is part 1, done on the 44K Xenopus platform. This dataset was used only for one pancreas experiment with several data points (control, 12h, 24h, 48h and frog). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.

2010-05-16 | E-GEOD-16074 | biostudies-arrayexpress

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part B

Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: co-expression design,development or differentiation design,reference design,time series design Overall design: Thyroid hormone (TH) controls remodeling of the liver. The microarray was carried out to identify changes in gene expression at different stages of development during metamorphosis. This is part 2, done on the 22K Xenopus platform version 1. This dataset was from livers of Xenopus tadpoles (NF52, NF62, and NF66). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.

2010-05-16 | E-GEOD-16017 | biostudies-arrayexpress

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C

Project description:Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. The first one studied gene expression changes at different developmental stages of Xenopus laevis during metamorphosis. The second array studies gene expression changes at varying times after the addition of TH to premetamorphic tadpoles. Keywords: co-expression design,development or differentiation design,reference design,time series design Overall design: Thyroid hormone (TH) controls remodeling of the pancreas. The microarray was carried out to identify changes in gene expression at different stages of development during metamorphosis.. This is part 3, done on the 22K Xenopus platform version 2. This dataset was from pancreas of Xenopus tadpoles (NF52, NF62, and NF66). Each was made in triplicate. Samples in all 3 parts of the study received the same thyroid hormone levels.

2010-05-16 | E-GEOD-16018 | biostudies-arrayexpress

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part B

2010-01-01 | GSE16017 | GEO

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A

2010-01-01 | GSE16074 | GEO

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part C

2010-01-01 | GSE16018 | GEO