Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of liver after SHAM or CLP with and without dexamethasone treatment

ABSTRACT: Study of the occurrence of glucocorticoid resistance after CLP induced sepsis in mice

ORGANISM(S): Mus musculus

PROVIDER: GSE160795 | GEO | 2021/02/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

ChIP-seq of liver after SHAM or CLP with and without dexamethasone treatment

Project description:Study of the occurrence of glucocorticoid resistance after CLP induced sepsis in mice

2021-02-01 | GSE161183 | GEO

RNA-seq of liver after SHAM or CLP with and without dexamethasone treatment [24hrs]

Project description:Study of the occurrence of glucocorticoid resistance after CLP induced sepsis in mice

2021-02-01 | GSE160830 | GEO

ChIP-seq of liver after SHAM or CLP with and without dexamethasone treatment

Project description:ChIP-seq of liver after SHAM or CLP with and without dexamethasone treatment

| PRJNA675862 | ENA

RNA-seq of liver after SHAM or CLP with and without dexamethasone treatment

Project description:RNA-seq of liver after SHAM or CLP with and without dexamethasone treatment

| PRJNA674518 | ENA

RNA-seq of liver after SHAM or CLP with and without dexamethasone treatment [24hrs]

Project description:RNA-seq of liver after SHAM or CLP with and without dexamethasone treatment [24hrs]

| PRJNA674606 | ENA

Burn-CLP

Project description:The experimental design included three biological replicates for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study Keywords: other

2005-09-20 | GSE1781 | GEO

Transcriptomic Profiling on Kidneys of Mice after Cecal Ligation and Puncture (CLP) Compared to Sham Operation

Project description:Sepsis is a severe clinical syndrome related to an exaggerated host immune response to infection as well as systematic inflammation and serious tissue damage. Sepsis-associated acute kidney injury (SA-AKI) is one of the most frequent and serious complications of sepsis. This study aimed to identify new mechanisms in SA-AKI through transcriptome profiling (RNA-seq).

2022-08-17 | GSE186822 | GEO

Differential Expression of microRNAs following activated protein C treatment in a rat model of septic shock

Project description:Sepsis induces systemic stress by augmenting inflammatory and pro-coagulant responses resulting in microvascular dysfunction and end organ failure, events modulated by the Protein C pathway. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene transcription yet their role in sepsis remains poorly defined. We hypothesized that aPC selectively alters the expression of specific miRNAs implicated in protection of hepatic function during septic shock. Male Sprague-Dawley rats underwent sham surgery or cecal ligation and puncture (CLP). Twenty-four later, animals were randomized and treated with aPC (1mg/kg) or vehicle (0.9% (w/v) saline) via an indwelling venous catheter at 12 hour intervals for 24 hours. Gene array was performed on hepatic RNA to determine miRNA expression, and predicted mRNA targets determined using a bioinformatics approach. Of 351 rat miRNAs examined by microarray hybridization, 17 were highly expressed during sepsis and restored to basal levels after aPC treatment. In silico analysis identified 9 miRNAs significantly regulating target genes of the focal adhesion pathway. These data suggest aPC treatment coordinates beneficial cytoprotective effects during sepsis by modulating miRNA expression. While translational effects remain to be fully elucidated in a clinical setting, we demonstrate herein the potential experimental and computational benefits for use of microRNA analysis in sepsis. 12 samples were analyzed. Microarray experiments were performed, in which liver tissue was harvested from variuous groups (Sham+Vehicle, Sham+aPC, CLP+Vehicle, CLP+aPC; n=3/group) and pooled.

2014-12-20 | E-GEOD-34790 | biostudies-arrayexpress

Host Responses to Sepsis Vary in Different Low-Lethality Murine Models

Project description:The CS and CLP murine models of intra-abdominal sepsis have unique transcriptomic respones 2 hrs, 1 and 3 days after sepsis We used mouse microarrays to detail the molecular profile of the events that occur following infection in two different sepsis models Infection protocol: Used the Cecal Ligation and Puncture (CLP) model and Cecal Slurry (CS) method in young mice.

2014-02-21 | E-GEOD-55238 | biostudies-arrayexpress

Whole transcriptome analysis of liver tissue in CLP mice and alpha-lactose treated mice

Project description:Sepsis is a syndromic response to infection and is frequently a final common pathway to death from many infectious diseases worldwide. The global burden of sepsis is difficult to ascertain, although a recent scientific publication estimated that there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for almost 20% of all global deaths.In this experiment, we systematically studied the gene expression changes in the liver of sepsis using septic mice and contributed to the rationalization of the immune to sepsis in mice. Administration of α-lactose to block Tim-3 signaling pathway significantly improved the survival of septic mice. In order to figure out the mechanisms of the α-lactose, we explored the immune changes in mice after α-lactose interference, rationalizing sepsis in mice, and exploring the potential of a-lactose to treat sepsis.

2022-03-02 | GSE197642 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data