Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Transcriptome of over expressed SLAMF6 isoform-3 in activated Jurkat cell line

ABSTRACT: SLAMF6 is a homotypic receptor of the Ig-superfamily associated with progenitor exhausted T cells. In humans, SLAMF6 has three splice isoforms involving its V-domain.We KO isoform 1 of SLAMF6 in a Jurkat cell line and harvest this cell line RNA using Bulk-RNA-Seq after activation in 5 time points. Comparing the results to WT Jurkat cell line, we analyzed the transcriptional landscape and showed that after activation SLAMF6 isoform 3 is the prominent expressed isoform, and that the KO Jurkat cells have a stronger cytotoxic phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE160817 | GEO | 2020/11/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

The Transcriptome of over expressed SLAMF6 isoform-3 in activated Jurkat cell line

Project description:The Transcriptome of over expressed SLAMF6 isoform-3 in activated Jurkat cell line

| PRJNA674593 | ENA

MS-based arginine monomethylation study in Jurkat PRMT7 KO cells

Project description:Effects of Prmt7 genetic deletion to arginine monomethylation in Jurkat T-ALL cell line. Analysis was made using two different Prmt7 KO and one control cell lines.

2022-03-28 | PXD032819 | JPOST Repository

Expression data from B6, Sle1b and Sle1b.BACSlamf6-H1 CD4+ T cells

Project description:We recently showed that the Slamf6 protein isoform Slamf6-H1 markedly diminishes T cell–dependent disease upon introduction of a Slamf6-H1–expressing transgene into the lupus-prone Sle1b mouse, which lacks this isoform. In this study we purified CD4+ T cells from Sle1b, Sle1b.Slamf6-H1, or B6 mice and a global gene expression profile was analyzed. Comparison of isolated cells from three strains of mice (12wk old females) at three time points of anti-CD3 activation with three biological replicates for each group (unless indicated otherwise).

2013-04-23 | E-GEOD-31733 | biostudies-arrayexpress

Identification of LEDGF-responsive genes in Jurkat cells

Project description:The LEDGF transcript from the PSIP1 gene was knocked down in Jurkat cells using RNAi technology. The resulting Jurkat-derived cell line (Jurkat-siJK2) was compared to a control cell line (wild type Jurkat) using microarray analysis. Genes identified as being modulated by LEDGF were preferential targets of HIV integration. Keywords: effects of gene knockdown

2007-04-13 | GSE7508 | GEO

role of miR-146a on Jurkat T cells

Project description:screenning the differentially expressed genes of Jurkat-FF3, Jurkat-miR146a, Jurkat-miR146a-sponge cell lines. To investigate the role of miR-146a on Jurkat T cells, we screened the differentially expressed genes of Jurkat-FF3 (as control), Jurkat-miR146a (as miR-146a overexpression cell line), Jurkat-miR146a-sponge (as miR-146a knock down cell line).

2010-04-03 | E-GEOD-21132 | biostudies-arrayexpress

ARID5B ChIP-seq in Jurkat

Project description:ChIP-seq analysis was performed in Jurkat cells (T-cell acute lymphoblastic leukemia cell line)

2018-01-12 | GSE97512 | GEO

Nef transfection of Jurkat T cells

Project description:Jurkat T cell line was transfected with SIV Nef controlled by an unducible promoter system. Nef was induced by addition of 10 micromolar pronasterone A and gene expression values were determined after 24 hrs. Control Jurkat cells were untransfected and treated with 10 micromolar pronasterone A and gene expressio values were determined after 24 hrs. Keywords: SIV Nef, Jurkat, pronasterone A

2006-07-25 | GSE4785 | GEO

RNA-seq analysis in Jurkat cells

Project description:RNA-seq analysis was performed in Jurkat cells (T-cell lymphoblastic leukemia cell line).

2016-12-31 | GSE81712 | GEO

H3K4me1 ChIP-seq analysis in Jurkat cells

Project description:ChIP-seq analysis was performed in Jurkat cells (T-cell acute lymphoblastic leukemia cell line)

2018-09-05 | GSE119439 | GEO

Expression data from B6, Sle1b and Sle1b.BACSlamf6-H1 CD4+ T cells

2013-04-23 | GSE31733 | GEO