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RNA sequencing in 12-week old orbital frontal cortex in circHomer1/Homer1b knockdown and control mice

ABSTRACT: These are RNA sequencing data from 12 week old orbital frontal cortex from mice who received a shRNA targeting circHomer1 and Homer1b (double knockdown) or control shRNA (scramble)

ORGANISM(S): Mus musculus

PROVIDER: GSE160874 | GEO | 2022/01/01

REPOSITORIES: GEO

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RNA sequencing in 12-week old orbital frontal cortex in circHomer1/Homer1b knockdown and control mice

Project description:RNA sequencing in 12-week old orbital frontal cortex in circHomer1/Homer1b knockdown and control mice

| PRJNA674708 | ENA

RNA-Seq of CircHomer1a shRNA Knockdown vs. scrambled shRNA Control Mouse Orbital Frontal Cortex

Project description:RNA-Seq of CircHomer1a shRNA Knockdown vs. scrambled shRNA Control Mouse Orbital Frontal Cortex

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RNA-Seq of CircHomer1a shRNA Knockdown vs. scrambled shRNA Control Mouse Orbital Frontal Cortex

Project description:We report the application of RNA-sequencing to profile gene expression changes associated with shRN- mediated knockdown of circHomer1a RNA in mouse orbital frontal cortex

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Effect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome

Project description:Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmental impact of juvenile exposure during a critical period of frontal cortex development, specifically that of the rat orbital neocortex between postnatal days 8 and 22. Agnostic shotgun proteomics was employed to discern the biomolecular shift within this rapidly developing brain region that is responsible for higher-order behavioral control. The orbital cortex neuroproteome was assessed between ETS-exposed and room-air control animals employing a label-free shotgun approach with data-independent acquisition. Following protein roll-up, a total of X protein were found statistically altered in quantity out of Y total proteins identified. These results implicate a prominent shift within metabolic processes and synaptic organization related to excitatory and inhibitory neurotransmission. Findings derived from this dataset may further our understanding of how secondhand smoke exposure can perturb the orbital frontal cortex and result in developmental behavioral disorders.

2018-12-17 | PXD011744 | Pride

Effect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome

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IgG4-ROD and orbital MALT lymphoma

Project description:The molecular pathogenesis of orbital lymphoproliferative disorders, such as immunoglobulin G4-related ophthalmic disease (IgG4-ROD) and orbital mucosa-associated lymphoid tissue (MALT) lymphoma, remains essentially unknown. Differentiation between the two disorders, which is important since work-up and treatment can vary greatly, is often challenging due to the lack of specific biomarkers. Although miRNAs play an important role in the regulation of carcinogenesis and inflammation, the relationship between miRNA and orbital lymphoproliferative diseases remains unknown. A comprehensive analysis of 2,565 miRNAs was performed in biopsied specimens and serum of 17 cases with IgG4-ROD and 21 cases with orbital MALT lymphoma. We identified specific miRNA signatures, their miRNA target pathways, and network analysis associated with IgG4-ROD and orbital MALT lymphoma. Machine-learning analysis identified miR-202-3p and miR-7112-3p as the best discriminators of IgG4-ROD and orbital MALT lymphoma, respectively. In the tissue pathway, Longevity regulating pathway in IgG4-ROD and MAPK signaling pathway in orbital MALT lymphoma were most enriched by downregulated miRNAs. This is the first evidence of the miRNA profile in biopsied specimens and serum of patients with IgG4-ROD and orbital MALT lymphoma. These data will be useful for developing diagnostic and therapeutic interventions, as well as elucidating of these disorders.

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Parkinson Disease Frontal Cortex ncRNA Profiling

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Transcriptomic profiling of human orbital fat and differentiating orbital fibroblasts

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Transcriptome Alterations in Myotonic Dystrophy Frontal Cortex

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Circular RNA expression analysis of orbital venous malformation [miRNA-Seq]

Project description:This research aimed to investigate the aberrant expression of circRNA, messenger RNA, and microRNA in orbital venous malformation. A competitive endogenous RNA network was constructed to elucidate their potential roles in orbital venous malformation.

2022-07-06 | GSE158793 | GEO

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