Genomics

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IL-36 and IL-17A Cooperatively Induce a Psoriasis-like Gene Expression Response in Human Keratinocytes


ABSTRACT: In this study we tested interactions between IL-36 and IL-17A in human keratinocytes. 24 hours of IL-36 stimulation in keratinocytes promoted IL-36, IL-17C, and characteristic psoriasis-related molecule expressions in normal human epidermal keratinocytes in dose-dependent manners as measured by mRNA and protein quantification. Overall design: 12 cultured samples of human keratinocytes stimulated with IL-36 and IL-17 family cytokines, as single cytokines and also as a combination were evaluated by gene expression profiling with Affymetrix U133 2.0Plus arrays

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: James Krueger  

PROVIDER: GSE160904 | GEO | 2021-12-31

REPOSITORIES: GEO

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