Skull and vertebral bone marrow are myeloid reservoirs for meninges and CNS parenchyma

ABSTRACT: EAE is a chronic demyelinating condition characterized by central nervous system immune infiltration. Spinal cord injury results in damage to the spinal cord, partially due to leukocyte infiltration and inflammatory contributions. Here we performed single-cell RNA-sequencing of spinal cord tissue to examine how CNS-infiltrating cells from different niches may play distinct roles in different disease pathogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE161034 | GEO | 2021/05/24

REPOSITORIES: GEO