Vitamin D Receptor binding and chromatin accessibility in mouse duodenal crypt and villus and colon epithelium

ABSTRACT: VDR is critical for Ca++ homeostasis. While its role in this process within the intestine has primarily been focused to the duodenal epithelium, we have uncovered a compensatory role for VDR in the colon in mediating Ca++ uptake. Here, we compare VDR genomic binding properties in the colon and duodenum using ChIP-seq. We also examine the chromatin accessibility between these intestinal regions.

ORGANISM(S): Mus musculus

PROVIDER: GSE161038 | GEO | 2023/11/06

REPOSITORIES: GEO