Temporal and dosage-dependent transcriptional response to SARS-CoV-2 in lung, trachea, brain, olfactory bulb and small intestine of Syrian golden hamsters

ABSTRACT: Here we report the transcriptional response to SARS-CoV-2 in Syrian golden hamsters and compare it to the host response against Influenza A virus. The virus replicates fast to high titers in the respiratory tract followed by a local and systemic inflammatory response. A roust IFN-I reponse is mounted and lasts at leaset fourteen days in distal tissues together with other lasting transcriptional changes.

ORGANISM(S): Mesocricetus auratus

PROVIDER: GSE161200 | GEO | 2020/11/11

REPOSITORIES: GEO