Genomics

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MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity [HITS-CLIP]

ABSTRACT: Neuron-enriched microRNAs (miRNAs), miR-9/9* and miR-124 (miR-9/9*-124), direct cell fate switching of human fibroblasts to neurons when ectopically expressed by repressing anti-neurogenic genes. How these miRNAs function after the onset of the transcriptome switch to a neuronal fate remains unclear. Here, we identified direct targets of miRNAs by Argonaute (AGO) HITS-CLIP as reprogramming cells activate the neuronal program and reveal the role of miR-124 that directly promotes the expression of its target genes associated with neuronal development and function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE161237 | GEO | 2021/05/25

REPOSITORIES: GEO

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