Dissecting the Epithelial and Immune Evolution during Colorectal Carcinogenesis by Single-Cell RNA Sequencing

ABSTRACT: Adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal carcinoma. However, cellular heterogeneity in aberrant epithelia and the complexity of tumor microenvironment limited the understanding of carcinogenesis. Here we performed a scRNA-seq survey from patient-matched samples, including blood, normal, para-cancer, polyp, and cancer tissues.

ORGANISM(S): Homo sapiens

PROVIDER: GSE161277 | GEO | 2021/12/30

REPOSITORIES: GEO