Fetuin A is an immunomodulator and therapeutic target for Heterotopic ossification and associated bone loss

ABSTRACT: Heterotopic ossification (HO), the pathologic growth of extra-skeletal bone, occurs as a common complication of trauma or in genetic disorders and can be disabling and lethal.We report that mice harboring injury-induced HO exhibit bone loss similar to the presentation of HO patients. Esepecially, Fetuin A dysregulation promotes immunosupression in HO lesion to link HO and bone loss.

ORGANISM(S): Mus musculus

PROVIDER: GSE161388 | GEO | 2022/11/02

REPOSITORIES: GEO