RNA-Seq analysis of P14 CD8+T cells in B16-GP tumors

ABSTRACT: CD8+ T cells play an important role in fighting against tumors. However, CD8+ T cells often become functionally impaired or “exhausted” in the tumor microenvironment. T cell exhaustion is a major hurdle that currently limits the efficacy of immunotherapeutic regimens. The exhausted T cell population is heterogeneous and contains T cells subsets at varying states of differentiation and with a range of effector functions and proliferative potential. Identification of exhausted T cell-specific markers will help to understand the heterogeneity of this population. Therefore, we have performed RNA-sequencing analysis of mouse tumor-infiltrating CD8+ T cells and splenic CD8+ T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE161425 | GEO | 2022/04/14

REPOSITORIES: GEO