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The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE161456 | GEO | 2023/11/13

REPOSITORIES: GEO

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The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells [cancer pathways]

Project description:The heavy metal Cadmium (Cd), a widespread environmental contaminant, poses serious hazards to human health, and is considered a metallohormone and carcinogen. In women with uterine fibroids, there is a significant association between blood Cd levels and fibroid tumor size. The aim of this study was to determine if benign uterine fibroid cells could be malignantly transformed in vitro by continuous Cd exposure, and if so, explore a molecular mechanism by which this could occur. We found when fibroid cells were exposed to 10 µM CdCl2 for 8 weeks, a robust and fast-growing Cd- Resistant Leiomyoma (CR-LM) culture was established. The CR-LM cells showed the ability to form viable colonies in soft agar, increased glycogen aggregates, enhanced cell motility, a higher percentage of cells in G2/M phase, and increased expression of the proliferation marker Ki-67. NanoString analysis showed downregulation of genes encoding for ECM components, such as collagens, fibronectins, laminins, and SLRP family proteins; whereas, genes involved in ECM degradation (MMP1, MMP3 and MMP10) were significantly upregulated. A volcano plot showed that the direction of expression changes of the top differentially genes favored cancer progression. Functional analysis by IPA predicted a significant inhibition of TGFβ signaling, leading to enhanced proliferation and attenuated fibrosis. Prolonged Cd exposure altered phenotypic characteristics and dysregulated genes in fibroid cells predicative of progression towards a cancer phenotype. Therefore, continuous Cd exposures changes the phenotype of benign fibroid cells in vitro and could possibly pose a health risk for women with uterine fibroids.

2023-11-13 | GSE161455 | GEO

The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells [cancer progression]

2023-11-13 | GSE161454 | GEO

The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells

Project description:The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells

| PRJNA678338 | ENA

Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-29 | GSE178790 | GEO

The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells [cancer pathways]

Project description:The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells [cancer pathways]

| PRJNA678340 | ENA

The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells [cancer progression]

Project description:The effects of the prolonged Cd exposure on gene expression changes in in Uterine Leiomyoma Cells [cancer progression]

| PRJNA678341 | ENA

Epigenome analysis of uterin leiomyoma and myometrium with or without leiomyoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-09-01 | E-GEOD-45189 | biostudies-arrayexpress

Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell-enriched Population by Stimulating Their Differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-01 | GSE138051 | GEO

Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

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MED12 Mutation Activates Tryptophan-Kynurenine-AHR pathway and Promotes Cell Growth in Human Uterine Leiomyoma.

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-01 | GSE204970 | GEO

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