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Gene expression in activated WT or PDK4 -/- CD4+ T cells

ABSTRACT: Activation of CD4+ T cells requires metabolic reprograming to sustain demands of cellular building blocks and ATP. Pyruvate dehydrogenase kinase (PDK) is an enzyme regulating pyruvate dehydrogenase complex subunit alpha 1 (PDHE1-alpha), which converts pyruvate to acetyl-CoA. Gene expression analysis of TCR-stimulated CD4+ T cells with PDK4 deletion exhibited the reduced calcium signaling and aerobic glycolysis pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE161653 | GEO | 2022/11/01

REPOSITORIES: GEO

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