ASPSCR1-TFE3 reprograms transcription by organizing enhancers around hexameric VCP [HiChIP]

ABSTRACT: ChIPseq experiments identify that ASPSCR1-TFE3 defines active enhancers across the genome and co-distributes with VCP/p97. RNAseq after knock-down of ASPSCR1-TFE3 or VCP, inhibition of VCP, or overexpression of each in alveolar soft part sarcoma cell lines demonstrates their co-dependence. HiChIP defines chromatin conformations that surround ASPSCR1-TFE3 targets and are lost on VCP knock-down.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162068 | GEO | 2023/01/01

REPOSITORIES: GEO