Transcriptomics

Dataset Information

0

RNA-seq analysis of rat cardiac fibroblast transcriptome at three distinct developmental ages


ABSTRACT: The purpose of this study was to map the cardiac fibroblast transcriptome at three distinct developmental ages to investigate age-dependent gene expression differences in these cells, which are critically important to extracellular matrix turnover and repair, the inflammatory process, and cardiac remodeling after injury. To do so we isolated RNA from Sprague Dawley rats at fetal, neonatal, and adult developmental stages and performed RNA-seq. Overall, we identified an array of transcriptomic differences with respect to developmental age that suggests that CFs increase expression of immune- and inflammation-associated genes with age, with a decrease in cardiac development-associated genes and pathways. These results reinforce established evidence of phenotypic heternogenity of CFs with respect to age.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE162277 | GEO | 2021/05/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-09-27 | GSE149699 | GEO
2018-07-04 | GSE87613 | GEO
2023-11-06 | PXD042021 | Pride
2011-08-31 | E-GEOD-23328 | biostudies-arrayexpress
2012-08-02 | E-GEOD-28723 | biostudies-arrayexpress
2024-02-28 | GSE255542 | GEO
2024-02-28 | GSE254914 | GEO
2003-10-24 | GSE776 | GEO
2023-11-22 | GSE226273 | GEO
2023-11-22 | GSE226272 | GEO