Comparing mRNA expression of Myc/NrasG12V and Myc/Akt1 driven liver tumors

ABSTRACT: To analyze mRNA expression of Myc/NrasG12V and Myc/Akt1 driven liver tumors (HCC), we generated HCCs with elevated MYC expression and activated Raf-MEK-ERK or Akt1 signaling. To trigger tumor development, we co-delivered transposable elements encoding for Myc and oncogenic NrasG12V or myristoylated Akt1 via hydrodynamic injection into the hepatocytes of C57BL/6 wildtype mice and analyzed the transcriptomes of the developed tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE162324 | GEO | 2020/12/01

REPOSITORIES: GEO