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Analysis of skin of keratinocyte-specific OTULIN-deficient mice by single-cell RNA-sequencing

ABSTRACT: In order to unravel the functional role of the linear deubiquitinase OTULIN, we performed single-cell RNA-sequencing on total skin of mice lacking OTULIN selectively in keratinocytes. Keratinocyte-specific OTULIN knock-out (KO) mice develop delineated inflammatory lesion. Through single-cell analysis on lesional and non-lesional skin of mice lacking OTULIN in keratinocytes, we could identify signalling pathways through which these inflammatory lesions appear, allowing us to get new insights on the molecular events that regulate skin homeostasis and mediate skin inflammation.

ORGANISM(S): Mus musculus

PROVIDER: GSE162394 | GEO | 2021/08/03

REPOSITORIES: GEO

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