Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML

ABSTRACT: We report that loss of EZH2 provides leukaemia cells with a selective growth advantage, which mediates chemotherapy resistance. This resistance is conferred by up regulation of direct and indirect EZH2 target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162623 | GEO | 2021/03/12

REPOSITORIES: GEO