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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162687 | GEO | 2020/12/05

REPOSITORIES: GEO

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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets.

Project description: Not available

| S-EPMC7816164 | biostudies-literature

Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets I

Project description:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigated transcriptional and functional heterogeneity of human TRM cells through study of donor-derived intestinal TRM cells from intestinal transplant recipients. Single-cell transcriptional profiling identified two distinct transcriptional states of CD8+ TRM cells, delineated by ITGAE and ITGB2 expression. We defined a transcriptional signature discriminating these two CD8+ populations, including differential expression of cytotoxicity- and residency-associated genes. Flow cytometry of recipient-derived cells infiltrating the graft and lymphocytes from healthy gut confirmed the two CD8+ TRM phenotypes. CD103+ CD8+ TRM cells produced IL-2, and demonstrated greater polyfunctional cytokine production, while β2-integrin+ CD69+ CD103- TRM cells had higher granzyme expression. Phenotypic and functional analysis of intestinal CD4+ T cells identified many parallels, including a distinct β2-integrin+ population. Together, these results describe the transcriptional, phenotypic, and functional heterogeneity of human intestinal CD4+ and CD8+ TRM cells.

2020-12-05 | GSE162685 | GEO

Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets II

2020-12-05 | GSE162686 | GEO