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Novel LncRNA and mRNA expression profiles of peripheral blood mononuclear cells in patients with systemic lupus erythematosus and healthy controls

ABSTRACT: The multi-system involvement and high heterogeneity lead to great challenge in the diagnosis and treatment of systemic lupus erythematosus (SLE). Long non-coding RNA is a type of RNA greater than 200 nucleotides that does not encode proteins. LncRNA is a key regulator of gene expression in the immune system and is involved in the pathogenesis of a variety of autoimmune diseases, including SLE. In this work, we performed transcriptome sequencing and microarray analysis of peripheral blood mononuclear cells (PBMC) from freshly isolated healthy controls (n=5) and SLE patients (n=5) to analyze the expression of novel lncRNAs and mRNAsand explore their potential as biomarkers and their correlation with clinical features.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162828 | GEO | 2021/01/06

REPOSITORIES: GEO

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