Effect of Ad5-porcine interferon-α pre-treatment in Ebola virus induced gene expression in pigs

ABSTRACT: Microarray analysis was done to compare the response of EBOV-infected pigs that were pre-treated with Ad5-porIFNα or PBS. At 3 days post EBOV infection, pigs that had been pre-treated with Ad5-porIFNα displayed upregulation of many genes related to the immune response in contrast to pigs treated with PBS. The largest category of induced genes included cytokines and chemokines that affect T-cell differentiation (IL27) and T-cell recruitment (CCL5, CCL23, CCL24, CXCL9, CXCL11)

ORGANISM(S): Sus scrofa

PROVIDER: GSE162846 | GEO | 2020/12/09

REPOSITORIES: GEO