Conserved DNA sequence features underlie pervasive RNA polymerase pausing

ABSTRACT: This study reveals widespread Pol II pausing at single-nucleotide resolution across the human genome with the majority of Pol II pauses occur outside of promoter-proximal gene regions primarily along the gene-body of transcribed genes. We show DNA sequence properties underlying widespread transcriptional pausing including a new pause motif. The study indicates pervasive sequence-induced transcriptional pausing in human cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162857 | GEO | 2021/03/23

REPOSITORIES: GEO