Transcriptomics

Dataset Information

0

M16-106 adult and pediatric ALL clinical trial - RNAseq dataset


ABSTRACT: Combining venetoclax, a selective BCL-2 inhibitor, with low-dose navitoclax, a BCL-XL/BCL-2 inhibitor, may potentiate therapeutic BCL-2 and BCL XL inhibition without dose-limiting thrombocytopenia associated with navitoclax monotherapy. The safety and preliminary efficacy of venetoclax with low-dose navitoclax and chemotherapy was assessed in this phase 1 dose escalation study (NCT03181126) in pediatric and adult patients with relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma. Forty-seven patients received treatment. A recommended phase 2 dose of 50 mg navitoclax for adults and 25 mg for patients <45 kg with 400 mg adult-equivalent venetoclax was identified. Delayed hematopoietic recovery was the primary safety finding. The complete remission rate was 60%, including responses in patients who had previously received hematopoietic cell transplantation or immunotherapy. Thirteen (28%) patients proceeded to transplantation or CAR T-cell therapy on study. Venetoclax with navitoclax and chemotherapy was well tolerated and had promising efficacy in this heavily pretreated patient population.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162894 | GEO | 2021/02/17

REPOSITORIES: GEO

Similar Datasets

2023-10-16 | GSE240444 | GEO
2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress
2021-12-22 | GSE159504 | GEO
2015-09-10 | E-GEOD-72355 | biostudies-arrayexpress
2015-06-05 | GSE55036 | GEO
2020-11-27 | GSE141572 | GEO
2021-06-21 | GSE151594 | GEO
2008-05-01 | GSE10841 | GEO
2022-06-15 | GSE173618 | GEO
2018-11-21 | GSE122510 | GEO