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Cytoprotective Nrf2 pathway is induced in chronically Txnrd1-deficient hepatocytes

ABSTRACT: Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons to some cellular reductases, including peroxiredoxins. Here we generated mice in which the txnrd1 gene, encoding Txnrd1, was specifically disrupted in all parenchymal hepatocytes. Keywords: Triplicate comparisons, two conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE16381 | GEO | 2009/06/03

SECONDARY ACCESSION(S): PRJNA115293

REPOSITORIES: GEO

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Transcription profiling of mouse with txnrd1 specifically disrupted in all parenchymal hepatocytes - reveals cytoprotective Nrf2 pathway is induced in chronically Txnrd1-deficient hepatocytes

Project description:Metabolically active cells require robust mechanisms to combat oxidative stress. The cytoplasmic thioredoxin reductase/thioredoxin (Txnrd1/Txn1) system maintains reduced protein dithiols and provides electrons to some cellular reductases, including peroxiredoxins. Here we generated mice in which the txnrd1 gene, encoding Txnrd1, was specifically disrupted in all parenchymal hepatocytes. Experiment Overall Design: Transcriptome analyses on whole mouse livers.

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