CCL22 mutations in chronic lymphoproliferative disorder of NK cells (CLPD-NK)

ABSTRACT: We engrafted empty vector, wild type CCL22, and Pro79Arg-CCL22 mutant-expressing NK-92 cells into NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ mice to assess in vivo function of detected CCL22 mutations. Engrafted Pro79Arg NK-92 cells recapitulated the phenotype of CLPD-NK patients with CCL22 mutations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE163864 | GEO | 2022/01/19

REPOSITORIES: GEO