Transcriptome profiles associated with selenium deficiency dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells

ABSTRACT: Hepatocellular carcinoma (HCC) cells show increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low efficacies due to resistance and off-target effects in HCC. Here we aimed to analyze oxidative stress-related gene expression profiles of two HCC cell lines. To identify important genes that cause resistance to reactive oxygen species (ROS), a model of oxidative stress upon selenium (Se) deficiency was utilized in which an affymetrix microarray data was generated for two isogenic HCC cell lines - HepG2 and HepG2-2.2.15 (Head-to-Tail HBV genome integration) that are either sensitive or resistant to Se deficiency dependent oxidative stress, respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE163950 | GEO | 2020/12/29

REPOSITORIES: GEO