Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

ABSTRACT: This study demonstrated that PDB has an epigenetic signature in the blood and that differentially methylated sites in white blood cells may be used as predictive markers of the disease. Many of the identified changes in DNA methylation were associated with genes that regulate osteoclast function, immune responses, host reponse to viral infection, pain pathways and pathways involved in mechanosensing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE163970 | GEO | 2021/06/03

REPOSITORIES: GEO