Astrocytes Tet1 regulates neuronal development and cognition through modulating GluA1

ABSTRACT: Using RNA sequencing, we found that Tet1 alters gene expression. Mechanistically, we found that Tet1 deficiency leads to the abnormal Ca2+ signaling by regulating the expression of GluA1, which can be rescued by ectectopic expression of GluA1. Collectively, our findings suggest that Tet1 plays important functions by regulating astrocytes Ca2+ signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE164025 | GEO | 2021/11/17

REPOSITORIES: GEO