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Whole-genome transcritome analysis of diet-induced murine NASH

ABSTRACT: Whole liver from mice with diet-induced nonalcoholic fatty liver disease (NASH) was subjected to bulk RNA-seq. Ingenuity pathway analysis implicated pathways related to the leukocyte adhesion and differentiation in the pathogenesis of NASH. Among the adhesion molecules expressed in endothelial cells, only Icam1 (Log2FC: 1.99; FDR: 1.55E-37) and Vcam1 (Log2FC: 1.93; FDR: 9.32E-35) were differentially upregulated in NASH liver.

ORGANISM(S): Mus musculus

PROVIDER: GSE164084 | GEO | 2021/02/01

REPOSITORIES: GEO

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Genome-wide transcriptome analysis of liver sinusoidal endothelial cells in the pathogenesis of NASH

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