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Transcriptome profiling of cold exposure induced browning of white fat

ABSTRACT: We revealed the common alterations and highlighted the differential effects between cold and β-AR agonists exposure on beige fat

ORGANISM(S): Mus musculus

PROVIDER: GSE164219 | GEO | 2021/05/25

REPOSITORIES: GEO

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Tanscriptome profiling of cold exposure induced browning of white fat

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2023-08-20 | GSE222424 | GEO

Methylation profiling of cold exposure induced browning of white fat

Project description:We set two groups of 2-month-old C57BL6/J male mice at either thermoneutral temperature of 30℃ or under cold stimulation at 4℃ for one week. To identify events vital to beige fat activation, we performed MeRIP-seq using mice subcutaneous adipose tissue (iWAT) and focused on differentially-expressed genes characterized significant upregulation.

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BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Project description:Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remains elusive. Here we found that BAF60a, a subunit of the SWI/SNF chromatin-remodeling complexes, serves an indispensible role in cold-induced thermogenesis in brown fat. BAF60a maintains chromatin accessibility for key thermogenic genes in close proximity to PPARg and EBF2 binding sites. Surprisingly, fat-specific BAF60a inactivation triggers more pronounced browning of inguinal white adipose tissue that is linked to induction of MC2R, a receptor for the pituitary hormone ACTH. Elevated MC2R expression sensitizes adipocytes and BAF60a-deficient adipose tissue to thermogenic activation in response to ACTH stimulation. These observations reveal an unexpected dichotomous role of BAF60a-mediated chromatin remodeling in transcriptional control of brown and beige gene programs and illustrate a pituitary-adipose signaling axis in the control of thermogenesis.

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Profiling of cold exposure induced browning of white fat

Project description:This SuperSeries is composed of the SubSeries listed below.

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Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis

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Transcriptome profiling of cold exposure induced browning of white fat

Project description:Transcriptome profiling of cold exposure induced browning of white fat

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Project description: Not available

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