Interleukin-1α mediates innate and acquired resistance to immunotherapy in melanoma

ABSTRACT: In a syngeneic mouse model of melanoma, we found that tumor size was inversely correlated with response to immunotherapy. Large tumors had higher levels of IL-1α, Th2 cytokines, granulocytic myeloid-derived suppressor cells (GMDSCs), and regulatory T cells but lower levels of IL-12, Th1 cytokines, and activated CD4+ and CD8+ T cells. Blocking IL-1 signaling decreased GMDSCs and their associated PD-L1 expression in the tumor microenvironment, and enhanced tumor-specific immunity.

ORGANISM(S): Mus musculus

PROVIDER: GSE164357 | GEO | 2021/02/04

REPOSITORIES: GEO