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Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling [in vivo]

ABSTRACT: Th1 cells were adoptively transferred into RAG1 KO mice from either wildtype (Il23rwt/eGFP) or KO (Il23reGFP/eGFP) donors. At the peak of disease in recipients of wildtype cells, the animals were euthanized and intestinal T cells were isolated from the chosen recipients of both wildtype and KO cells for 10x massively parallel single-cell RNA-sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE164519 | GEO | 2021/05/01

REPOSITORIES: GEO

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Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling

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Identification of IL-23 target genes in intestinal CD4+ T cells

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IgA impact on distal small intestine after colonization with B. thetaiotaomicron

Project description:Wildtype B6, Rag1-/- B6 and Rag1-/- B6 mice harboring the 225.4 IgA producing hybridoma were colonized for 10 days with Bacteroides thetaiotaomicron Keywords: RNA Expression Array

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