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The effect of berberine upon HepG2 cell viability

ABSTRACT: Berberin has been shown to inhibit HepG2 cell viability. This study aims to determine the genes regulated by berberine and clarify the possible molecular mechanism underlying the action.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE164561 | GEO | 2024/01/08

REPOSITORIES: GEO

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The effect of berberine upon 3T3L1 preadipocytes differentiation

Project description:Berberin has been shown to inhibit 3T3L1 preadipocytes differentiation. This study aims to determine the genes regulated by berberine and clarify the possible molecular mechanism underlying the action.

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The effect of berberine upon AAPH-damaged C17.2 neural stem cells

Project description:Berberine shows protective effect against AAPH-damaged C17.2 neural stem cells. This study aims to determine the genes regulated by berberine and clarify the possible molecular mechanism underlying the action.

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MicroRNA expression profiling of HepG2 liver cells after berberine chloride treatment

Project description:Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of pharmacological effects including anti-cancer effects. Since xenobiotic drug-induced micoRNAs have recently emerged as key regulators in guiding their pharmacological effects and toxicity, we were interested in whether or not micoRNA expression was differentially altered by berberine treatment in HCC. Here, we used miRNA microarray to analyze microRNA expression profiles of HepG2 human hepatoma cell line after berberine chloride treatment or 0.08% DMSO as control. Comparing miRNA profiles of 40 M-BM-5M-BM--M berberine-treated HepG2 human hepatoma cell line to those of control cells sampled after 2 and 4 hours treatment. A 50 mM stock solution of Berberine chloride was prepared in DMSO. Cells were treated with 40 M-BM-5M-BM--M berberine chloride or 0.08% DMSO as control.

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MicroRNA expression profiling of HepG2 liver cells after berberine chloride treatment

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Project description:This study aims to identify the underlying crucial proteins and regulatory networks associated with berberine treatment in colon cancer by using both proteomics analyses. Overall,this study shed a light for elucidating the related regulatory signalling pathways and discovering potential targets for berberine in colon cancer.

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Combined use of astragalus polysaccharide and berberine attenuates insulin resistance in IR-HepG2 cells via regulation of the gluconeogenesis signaling pathway

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