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Age-associated alteration of gene expression patterns in mouse oocytes

ABSTRACT: Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice using the NIA 22K 60-mer oligo microarray. Keywords: other

ORGANISM(S): Mus musculus

PROVIDER: GSE1646 | GEO | 2004/08/20

SECONDARY ACCESSION(S): PRJNA90699

REPOSITORIES: GEO

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Age-associated alteration of gene expression patterns in mouse oocytes

Project description:Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice using the NIA 22K 60-mer oligo microarray.

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Transcriptional profiling of cumulus cells differentiation throughout oocyte competence acquisition in the murine ovarian follicles.

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