Epigenetic profiling of young and aged spermatogonial stem cells (ChIP-Seq)

ABSTRACT: Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. Epigenetic profiling revealed reduced H3K27me3 deposition at numerous pro-differentiation genes during SSC differentiation as well as aberrant H3K27me3 distribution at genes in Wnt and TGF-β signaling upon aging.

ORGANISM(S): Mus musculus

PROVIDER: GSE164603 | GEO | 2021/06/14

REPOSITORIES: GEO