Epigenetic profiling of young and aged spermatogonial stem cells (RRBS)

ABSTRACT: Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. Aged SSCs exhibited gene body hypomethylation, which is accompanied by an elevated 5hmC level.

ORGANISM(S): Mus musculus

PROVIDER: GSE164606 | GEO | 2021/06/14

REPOSITORIES: GEO