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Stress-inducible gene Atf3 dictates a dichotomous macrophage activity in chemotherapy-enhanced lung colonization

ABSTRACT: Chemotherapy can be a double-edged sword, enhancing cancer progression even while killing cancer cells. This effect is often mediated by stresses on host cells. We found that pre-treatment of mice with cyclophosphamide before cancer cell injection increases the amount of cancer cell colonization of the lung. We determined this effect is at least partially dependent on the stress-inducible gene, Atf3, in monocytes/macrophages. We used microarrays to profile gene expression in WT/KO lung monocytes/macrophages after chemotherapy treatment and intravenous breast cancer cell injection. This was in order to find candidate genes that mediated the colonization-exacerbating role of chemotherapy.

ORGANISM(S): Mus musculus

PROVIDER: GSE164611 | GEO | 2021/08/03

REPOSITORIES: GEO

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Defining the microglia transcriptome during disease progression in ALS transgenic mice

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2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress

Stress-inducible gene Atf3 dictates a dichotomous macrophage activity in chemotherapy-enhanced lung colonization

Project description:Stress-inducible gene Atf3 dictates a dichotomous macrophage activity in chemotherapy-enhanced lung colonization

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Transcription profiling of mouse bone marrow-derived macrophages simulated with LPS, time series

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2009-04-04 | E-GEOD-14769 | biostudies-arrayexpress

Defining the microglia transcriptome during disease progression in ALS transgenic mice

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2013-07-10 | E-GEOD-36904 | biostudies-arrayexpress

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse [RNAseq]

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2022-12-31 | GSE221925 | GEO

Stress-Inducible Gene Atf3 Dictates a Dichotomous Macrophage Activity in Chemotherapy-Enhanced Lung Colonization.

Project description: Not available

| S-EPMC8304704 | biostudies-literature

Single cell RNA sequencing of aortic CX3CR1-derived monocyte/macrophage from atherosclerotic aorta during progression and regression

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2019-02-21 | GSE123587 | GEO

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