Expression data from stabilized epithelial pancreatic cancer cells

ABSTRACT: Pancreatic ductal adenocarcinoma is therapeutically recalcitrant and metastatic. Epithelial to mesenchymal transition (EMT) is associated with metastasis, however, a causal connection needs further unraveling. We explored the impact of stabilized EMT states on PDAC metastasis through the use of genetically-engineered mouse models that exhibit a stabilized epithelial phenotype through the deletion of EMT-driving transcription factors Snail and Twist together We examined the cancer cell-intrinsic pathways associated with stabilized epithelial pancreatic adenocarcinoma cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE164612 | GEO | 2021/04/13

REPOSITORIES: GEO