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TXN, a Xanthohumol Derivative, Significantly Attenuates High-Fat Diet Induced Hepatic Steatosis In Vivo by Antagonizing PPARγ

ABSTRACT: We performed unbiased transcriptional profiling of livers from mice to determine mechanisms by which xanthohumol and tetrahydroxanthohumol supplementation could ameliorate hepatosteatosis induced by a HFD at the transcriptional level. We conducted RNA-seq analysis of total RNA of livers obtained from mice after 16 weeks on the diet. Analysis revealed changes in gene expression that suggested these hop-derived compounds antagonize the nuclear receptor PPARγ.

ORGANISM(S): Mus musculus

PROVIDER: GSE164636 | GEO | 2021/05/18

REPOSITORIES: GEO

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